PEDF: The link between Obesity and Type 2 Diabetes?

Stereoscopic model of pigment epithelium-derived factor derived from the crystal structure
Stereoscopic model of PEDF

Link between obesity and diabetes discovered

Researchers at Monash University (led by Associate Professor Matthew Watt), have discovered that fat cells release a novel protein called PEDF (pigment epithelium-derived factor), which triggers a chain of events and interactions that lead to development of Type 2 diabetes.

According to Dr. Watt:

  • When PEDF is released into the bloodstream, it causes the muscle and liver to become desensitized to insulin. The pancreas then produces more insulin to counteract these negative effects
  • This insulin release causes the pancreas to become overworked, eventually slowing or stopping insulin release from the pancreas, leading to Type 2 diabetes.
  • It appears that the more fat tissue a person has the less sensitive they become to insulin. Therefore a greater amount of insulin is required to maintain the body’s regulation of blood-glucose.

Our research was able to show that increasing PEDF not only causes Type 2 diabetes like complications but that blocking PEDF reverses these effects.

In fact, after blocking the secretion of PEDF in test subjects, the body was able to return to being insulin-sensitive and therefore did not need excess insulin to remain regulated.

This research may be a significant breakthrough in explaining the reasons why obesity triggers the onset of Type 2 Diabetes.

Until now scientists knew there was a very clear pattern and had strong suspicions that a link existed between the two conditions, but our understanding of the chain of events that are caused by the release of PEDF shows a causal link, Dr. Watt said.

Type 2 diabetes patients will benefit knowing the two conditions are linked.

We already know that weight-loss generally improves the management of blood glucose levels in diabetes patients.

Researchers can now move forward knowing this link exists and can begin to design new drugs to improve the treatment of Type 2 diabetes….

pedf lifestyle

…or perhaps, instead of looking for a cure for this completely preventable lifestyle disease, we could throw some cash at health promotion and/or disease prevention.

fit lifestyle equation


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  1. Obesity and diabetes is a growing problems nowadays. It is caused by todays lifestyle which does not involve lots amount of exercise. Most people are just happy sitting in their office chair and they do not even want to sweat.

  2. Being obese means having more adipose tissue. Adipose tissue is one the body’s tissues which express PEDF at very high levels. High levels = diabetes type 2.  I think a better approach to treating type 2 diabetes is have people manage their weight better not taking neutralizing antibodies raised against PEDF.

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