Capsaicin for Weight Loss

I’ve got some interesting research for everyone out there trying to drop a few pounds.

Published in the journal Obesity, researchers have found that topical application of 0.075% capsaicin to male mice fed a high-fat diet significantly reduced weight gain and visceral fat.  In addition…

  • Fat cells were markedly smaller in the mesenteric and epididymal adipose tissues of mice treated with capsaicin cream.
  • The capsaicin treatment also lowered serum levels of fasting glucose, total cholesterol, and triglycerides
  • increased expression of adiponectin and other adipokines – leading to increased fat burning and insulin sensitivity
  • and reduced expression of tumor necrosis factor-α and IL-6 – leading to reduced inflammation

fat mouse skinny mouse obesity longevity


In short, the “hot sauce” mice lost weight and got healthier.

Note – This research is very, very, very preliminary and it will be a while before human research is conducted.

However, nothing is stopping you from buying a tube of 0.075% capsaicin and smearing it on your jelly-belly and love handles. But remember, if you’re going to play lab rat, make sure not to get the capsaicin cream into your eyes…that’s gonna sting.

Is capsaicin safe?

According to WebMD, experts in the United States generally consider capsaicin to be safe. But it can cause some unpleasant effects, especially for those who are not used to it.

Begin with small amounts, and increase the amount as you get used to it. You can put the creams on your skin up to 4 times a day. You may feel a burning or itching sensation the first few times you use the cream, but this will gradually decrease with each use.

Wash your hands thoroughly after each use to avoid getting the cream in your eyes or on other moist mucous membranes, where it can cause a burning sensation. Do not use the cream on areas of broken skin.[/box]


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  1. This stuff can be found at most pharmacies in the US . The product is generally used for pain, especially neuralgia. If you try it, be prepared for some intense local burning, flushing, etc that subsides after a few minutes. As the article stated, start with a small area 1-2 times daily and increase if tolerated up to 4 times daily. It is also availabe in a lower concentration (0.025%) so be sure to grab the right one. Oh and BTW, I’m a registered pharmacist in PA.

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